Although they occur in a wide variety of habitat types, from deserts and chaparral to open forests across Oregon, Western rattlesnakes usually occur near rocks, cliffs, or downed logs. They overwinter in dens typically located on south-facing rocky hillsides exposed to sunshine.
Western rattlesnakes feed mainly on small mammals, including mice, gophers, squirrels and rabbits, but will also take birds lizards, and amphibians.