The Little pocket mouse is one of the smallest rodents in North America and certainly the smallest in Oregon. The dorsal pelage is pinkish buff to ocherous buff with overlying blackish hairs; the venter is buff. The tail is bicolored.

In Oregon, this mouse occurs in Harney and Malheur counties.

They exhibit their greatest activity from spring through autumn and spend a large portion of their lives in burrows below the surface of the ground. In winter, they remain underground continuously, relying on stored seeds for energy. When active on the surface, a large portion of their time is spent searching beneath shrubs for seeds. Items are identified as seeds by touch and placed in their pouches by use of the forefeet.