These lizards are found in open desert shrublands, particularly where islands of sand have accumulated around shrubs and are absent where a dense grass understory would inhibit their ability to run.
The Long-nosed leopard lizard eats large insects, such as grasshoppers, crickets, and beetles, and also takes small vertebrates, including pocket mice, side-blotched lizards, whiptails, and Western fence lizards. Some plant material (flowers, berries) is eaten when available.