The Siskiyou chipmunk is slightly smaller than the Townsend's chipmunk and slightly larger than the Allen's chipmunk. The pelage is marked with five dark and four light stripes on the dorsum; the middorsal stripe is usually black and nearly always darker than the other four dark stripes. The sides of the face are marked with three brown and two light gray stripes; a patch behind the ear is light gray.
It occurs in Curry, Josephine and Jackson counties south of the Rogue River; in extreme western Klamath County; in extreme eastern Douglas and Lane counties; and in extreme southeastern Linn County.
Siskiyou chipmunks exhibit three diurnal peaks of activity: an early morning peak, a midday peak, and the maximum peak in early evening.